Drug class profile · refreshed daily from federal data

alpha-Adrenergic Agonist

5 molecules in this class, $153.5M combined CY2024 Part D spend across 2.5M claims. Class-level guide below for benefits decision-makers: where the money lives, where the savings live.

Last updated 15 Oct 2026

NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annualOrange Book: weeklyShortages: daily

Class summary at a glance.

Every drug in the alpha-Adrenergic Agonist class tracked across NADAC, Part D Formulary, Part D Spending, FDA Orange Book, and shortage data. Ranked below by CY24 Part D spend. Click any molecule for the full drug profile.

Molecules in class: 5tracked in Part D
CY24 Part D spend: $153.5Mcombined across class
Total Rx claims: 2.5M761K unique beneficiaries
Generic mfrs (active): 16across all molecules

Every drug in this class, ranked by Part D spend.

CY2024 dataCMS Part D Spending Dashboard

Midodrine

2.5M Part D claims (CY24) · 761K beneficiaries · First FDA approval: 2003-09-11

13 generic mfrs 0 plans require PA Discontinued

Low NADAC$0.074

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Avg plan cost$0.111

Part D spend $153.5M 2× spread, current vs floor

Class share

100%

of class CY24 spend

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Epinephrine In Sodium

Brand: Adrenalin (epinephrine in sodium chloride) · — Part D claims (CY24) · First FDA approval: 2024-10-04

Brand-only (no generics)

Low NADAC—

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Avg plan cost—

Part D spend —

Class share

of class CY24 spend

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Epineprine

Brand: Adrenalin · — Part D claims (CY24) · First FDA approval: 2022-01-07

Brand-only (no generics)

Low NADAC—

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Avg plan cost—

Part D spend —

Class share

of class CY24 spend

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Lidocaine Hci and Epinephrine

— Part D claims (CY24) · First FDA approval: 2019-10-21

3 generic mfrs Active FDA shortage

Low NADAC—

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Avg plan cost—

Part D spend —

Class share

of class CY24 spend

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Lidocaine and Epinephrine

Brand: Flavalta · — Part D claims (CY24) · First FDA approval: 1985-09-13

Brand-only (no generics)

Low NADAC—

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Avg plan cost—

Part D spend —

Class share

of class CY24 spend

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Class summary at a glance.

Every drug in this class, ranked by Part D spend.

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