Azelastine and Fluticasone vs Bepotastine Besilate — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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11 dimensions

Histamine-1 Receptor Antagonist

Azelastine and Fluticasone

Brand: DYMISTA

First FDA approval: 2016-10-01

Histamine-1 Receptor Antagonist

Bepotastine Besilate

Brand: Bepreve

First FDA approval: 2009-09-08

Lowest NADACAcquisition cost floor across all NDCs

$2.26Per unit

$13.03Per unit

Average NADACAcross all dosage forms and strengths

$3.98Up to $9.15

$17.35Up to $55.94

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

44 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

—Full year

$16.6MFull year

Part D claims (CY24)Total fills, all strengths

—— beneficiaries

101K32K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

—Per claim, all NDCs

$165Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

3Limited friction

7Limited friction

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

NoBrand-only

Yes4 manufacturers