Buprenorphine and Naloxone vs Buprenorphine — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Partial Opioid Agonist

Buprenorphine and Naloxone

Brand: Buprenorphine HCl and Naloxone HCl

First FDA approval: 2013-02-22

Partial Opioid Agonist

Buprenorphine

Brand: BELBUCA

First FDA approval: 2005-05-25

Lowest NADACAcquisition cost floor across all NDCs

$0.481Per unit

$0.294Per unit

Average NADACAcross all dosage forms and strengths

$3.09Up to $21.14

$25.64Up to $131.09

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

1539 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

—Full year

$536.9MFull year

Part D claims (CY24)Total fills, all strengths

—— beneficiaries

1.7M350K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

—Per claim, all NDCs

$317Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

631Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only

Yes15 manufacturers