Chlorpromazine vs Fluphenazine — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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11 dimensions

Phenothiazine

Chlorpromazine

Brand: ChlorproMAZINE Hydrochloride

First FDA approval: 1974-07-25

Phenothiazine

Fluphenazine

Brand: Fluphenazine Hydrochoride

First FDA approval: 1988-08-25

Lowest NADACAcquisition cost floor across all NDCs

$0.186Per unit

$0.218Per unit

Average NADACAcross all dosage forms and strengths

$0.468Up to $0.727

$1.24Up to $9.74

Generic manufacturersActive ANDA holders — FDA Orange Book

2272 total ANDAs filed

2270 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$75.5MFull year

$39.3MFull year

Part D claims (CY24)Total fills, all strengths

371K65K beneficiaries

327K46K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$204Per claim, all NDCs

$120Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

361Substantial friction

373Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

DiscontinuedSee drug profile

Generic availableFDA Orange Book

Yes22 manufacturers