Emtricitabine, Rilpivirine Hydrochloride, and Tenofovir Alafenamide vs Emtricitabine and Tdf — Cost, Coverage & Plan Comparison

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Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor

Emtricitabine, Rilpivirine Hydrochloride, and Tenofovir Alafenamide

Brand: ODEFSEY

First FDA approval: 2016-03-01

Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor

Emtricitabine and Tdf

First FDA approval: 2022-12-05

Lowest NADACAcquisition cost floor across all NDCs

$130.35Per unit

—Per unit

Average NADACAcross all dosage forms and strengths

$130.35Up to $130.35

—

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

—Full year

Part D claims (CY24)Total fills, all strengths

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only