Estrogens, Conjugated vs Estradiol — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

Drug 1

Drug 2

Drug 3 (optional)

Drug 4 (optional)

Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Estrogen

Estrogens, Conjugated

Brand: Conjugated Estrogens

First FDA approval: 2004-09-01

Estrogen

Estradiol

Brand: Climara

First FDA approval: 1994-12-22

Lowest NADACAcquisition cost floor across all NDCs

$5.24Per unit

$0.059Per unit

Average NADACAcross all dosage forms and strengths

$6.51Up to $6.95

$19.50Up to $925.92

Generic manufacturersActive ANDA holders — FDA Orange Book

15 total ANDAs filed

2198 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$367.7MFull year

$605.7MFull year

Part D claims (CY24)Total fills, all strengths

897K383K beneficiaries

8.0M3.6M beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$410Per claim, all NDCs

$75Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

95Minimal friction

171Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

14Limited friction

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes1 manufacturers

Yes21 manufacturers