Fluconazole vs Efinaconazole — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Azole Antifungal

Fluconazole

Brand: Diflucan

First FDA approval: 1993-12-23

Azole Antifungal

Efinaconazole

Brand: JUBLIA

First FDA approval: 2014-06-06

Lowest NADACAcquisition cost floor across all NDCs

$0.213Per unit

—Per unit

Average NADACAcross all dosage forms and strengths

$0.348Up to $0.511

—

Generic manufacturersActive ANDA holders — FDA Orange Book

1754 total ANDAs filed

33 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$55.1MFull year

$179.1MFull year

Part D claims (CY24)Total fills, all strengths

5.7M3.5M beneficiaries

154K59K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$10Per claim, all NDCs

$1,164Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

82Minimal friction

2Minimal friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes17 manufacturers

Yes3 manufacturers