Ospemifene vs Clomiphene — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Drug 2

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Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Estrogen Agonist/Antagonist

Ospemifene

Brand: Osphena

First FDA approval: 2023-04-01

Estrogen Agonist/Antagonist

Clomiphene

Brand: CLOMID

First FDA approval: 2022-09-09

Lowest NADACAcquisition cost floor across all NDCs

$8.16Per unit

$6.64Per unit

Average NADACAcross all dosage forms and strengths

$8.16Up to $8.16

$7.40Up to $11.16

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

66 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$11.4MFull year

$1.4MFull year

Part D claims (CY24)Total fills, all strengths

25K8K beneficiaries

7K2K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$456Per claim, all NDCs

$218Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

38Minimal friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only

Yes6 manufacturers