Oxycodone vs Fentanyl Transdermal — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Opioid Agonist

Oxycodone

Brand: OXAYDO

First FDA approval: 2000-08-31

Opioid Agonist

Fentanyl Transdermal

First FDA approval: 2020-02-28

Lowest NADACAcquisition cost floor across all NDCs

$0.045Per unit

$5.69Per unit

Average NADACAcross all dosage forms and strengths

$2.87Up to $32.73

$15.74Up to $36.36

Generic manufacturersActive ANDA holders — FDA Orange Book

1867 total ANDAs filed

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$737.4MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

14.7M4.7M beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$50Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

254Substantial friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes18 manufacturers

NoBrand-only