Peginterferon Beta-1A vs Interferon Beta-1A — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Interferon beta

Peginterferon Beta-1A

Brand: Plegridy

First FDA approval: 2014-08-15

Interferon beta

Interferon Beta-1A

Brand: AVONEX

First FDA approval: 2002-03-07

Lowest NADACAcquisition cost floor across all NDCs

—Per unit

$1848.67Per unit

Average NADACAcross all dosage forms and strengths

—

$6498.44Up to $8827.29

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$60.0MFull year

$468.4MFull year

Part D claims (CY24)Total fills, all strengths

6K1K beneficiaries

50K8K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$9,879Per claim, all NDCs

$9,323Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

214Substantial friction

497Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

24Limited friction

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only