Ramelteon vs Tasimelteon — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Melatonin Receptor Agonist

Ramelteon

Brand: Rozerem

First FDA approval: 2005-07-22

Melatonin Receptor Agonist

Tasimelteon

Brand: Hetlioz

First FDA approval: 2014-04-04

Lowest NADACAcquisition cost floor across all NDCs

$0.717Per unit

$400.17Per unit

Average NADACAcross all dosage forms and strengths

$1.59Up to $12.45

$400.17Up to $400.17

Generic manufacturersActive ANDA holders — FDA Orange Book

99 total ANDAs filed

33 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$37.4MFull year

$143.5MFull year

Part D claims (CY24)Total fills, all strengths

359K119K beneficiaries

6K1K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$104Per claim, all NDCs

$22,571Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

235Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

1Limited friction

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes9 manufacturers

Yes3 manufacturers