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Live data · NADAC + Part D CY24 · reviewed daily

Adapalene (DIFFERIN)

Adapalene regulates cell growth and differentiation, used in dermatology and certain cancers.

First FDA approval2009-09-15
Generic availableYes · 6 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$4.9M in CY2024 Part D spend15K claims · 8K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.495/unit
10 NDCs benchmarked, lowest of all strengths.
Average NADAC
$2.11
Across all dosage forms in distribution.
Highest NADAC
$11.27
Wide spread — brand-strength NDCs still in market.
Plans with PA
34 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Adapalene used for?

Adapalene regulates cell growth and differentiation, used in dermatology and certain cancers.

Is there a generic for Adapalene?

Yes. 7 ANDAs filed at FDA, 6 generic manufacturers currently shipping.

How much does my plan pay for Adapalene?

Across 329 Part D plans, Adapalene averages $2.11/unit (NADAC). Lowest available: $0.495/unit. Highest in distribution: $11.27/unit.

Is Adapalene on the FDA shortage list?

No. Adapalene is not currently on the FDA Drug Shortage Database.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Retinoid6 alternatives in D1
01
Acitretin
Retinoid
$2.20Lowest NADAC
6Generic mfrs
$20.7MCY24 Part D spend
Compare →
02
Adapalene Gel Usp,
Retinoid
$0.495Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Adapalene and Benzoyl Peroxide
Brand: EPIDUO
$0.285Lowest NADAC
7Generic mfrs
CY24 Part D spend
Compare →
04
Adapalene and Benzoyl Peroxide Gel,
Retinoid
$0.285Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Adapalene and Benzoyl Peroxide Topical
Brand: ADAPALENE AND BENZOYL PEROXIDE
$0.626Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
06
Alitretinoin
Brand: PANRETIN
Lowest NADAC
0Generic mfrs
$1.5MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (9 approvals on file) · NADAC unit costs: CMS NADAC weekly file (10 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.