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Live data · NADAC + Part D CY24 · reviewed daily

Alosetron (LOTRONEX)

Serotonin-3 Receptor Antagonist class · 4 generic manufacturers · 8 ANDAs filed at FDA.

First FDA approval2015-05-26
Generic availableYes · 4 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$14.6M in CY2024 Part D spend20K claims · 5K beneficiaries · 329 plans surveyed

Lowest NADAC
$2.22/unit
10 NDCs benchmarked, lowest of all strengths.
Average NADAC
$3.03
Across all dosage forms in distribution.
Highest NADAC
$3.85
Range is tight.
Plans with PA
416 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Alosetron used for?

Alosetron is a Serotonin-3 Receptor Antagonist medication tracked in Medicare Part D.

Is there a generic for Alosetron?

Yes. 8 ANDAs filed at FDA, 4 generic manufacturers currently shipping.

How much does my plan pay for Alosetron?

Across 329 Part D plans, Alosetron averages $3.03/unit (NADAC). Lowest available: $2.22/unit. Highest in distribution: $3.85/unit.

Is Alosetron on the FDA shortage list?

No. Alosetron is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Serotonin-3 Receptor Antagonist5 alternatives in D1
01
Fosnetupitant and Palonosetron
Brand: AKYNZEO
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
02
Granisetron
Brand: Granisetron
$1.10Lowest NADAC
13Generic mfrs
$11.1MCY24 Part D spend
Compare →
03
Netupitant and Palonosetron
Brand: AKYNZEO
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Ondansetron
Brand: ONDANSETRON
$0.064Lowest NADAC
19Generic mfrs
$218.9MCY24 Part D spend
Compare →
05
Palonosetron
Brand: Palonosetron
Lowest NADAC
13Generic mfrs
$409,092CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (10 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.