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Live data · NADAC + Part D CY24 · reviewed daily

Amitriptyline

Amitriptyline treats depression and chronic pain by blocking reuptake of serotonin and norepinephrine.

First FDA approval1977-11-21
Generic availableYes · 10 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$82.0M in CY2024 Part D spend5.7M claims · 1.5M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.035/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.035
Across all dosage forms in distribution.
Highest NADAC
$0.035
Range is tight.
Plans with PA
576 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema9 entries indexed · 4 visible
What is Amitriptyline used for?

Amitriptyline treats depression and chronic pain by blocking reuptake of serotonin and norepinephrine.

Is there a generic for Amitriptyline?

Yes. 60 ANDAs filed at FDA, 10 generic manufacturers currently shipping.

How much does my plan pay for Amitriptyline?

Across 329 Part D plans, Amitriptyline averages $0.035/unit (NADAC). Lowest available: $0.035/unit. Highest in distribution: $0.035/unit.

Is Amitriptyline on the FDA shortage list?

No. Amitriptyline is not currently on the FDA Drug Shortage Database.

5 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Tricyclic Antidepressant6 alternatives in D1
01
Amoxapine
Tricyclic Antidepressant
Lowest NADAC
2Generic mfrs
$278,639CY24 Part D spend
Compare →
02
Clomipramine
Brand: ANAFRANIL
$0.203Lowest NADAC
13Generic mfrs
$22.2MCY24 Part D spend
Compare →
03
Desipramine
Brand: Desipramine Hydrochloride
$0.146Lowest NADAC
5Generic mfrs
$4.9MCY24 Part D spend
Compare →
04
Doxepin
Brand: Doxepin
$0.078Lowest NADAC
25Generic mfrs
$99.4MCY24 Part D spend
Compare →
05
Imipramine
Tricyclic Antidepressant
$0.083Lowest NADAC
7Generic mfrs
$6.9MCY24 Part D spend
Compare →
06
Nortriptyline
Brand: PAMELOR
$0.123Lowest NADAC
5Generic mfrs
$31.8MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.