A BuiltForAI Property
Live data · NADAC + Part D CY24 · reviewed daily

Apremilast (Otezla)

OTEZLA/OTEZLA XR, an inhibitor of phosphodiesterase 4 (PDE4), is indicated for the treatment of: Adult patients with: Active psoriatic arthritis ( 1.1 ) Plaque psoriasis who are candidates for phot....

First FDA approval2020-02-26
Generic availableYes · 5 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$1.68B in CY2024 Part D spend332K claims · 61K beneficiaries · 329 plans surveyed

Lowest NADAC
$89.95/unit
3 NDCs benchmarked, lowest of all strengths.
Average NADAC
$93.18
Across all dosage forms in distribution.
Highest NADAC
$98.89
Range is tight.
Plans with PA
1472 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Apremilast used for?

OTEZLA/OTEZLA XR, an inhibitor of phosphodiesterase 4 (PDE4), is indicated for the treatment of: Adult patients with: Active psoriatic arthritis ( 1.1 ) Plaque psoriasis who are candidates for phot....

Is there a generic for Apremilast?

Yes. 15 ANDAs filed at FDA, 5 generic manufacturers currently shipping.

How much does my plan pay for Apremilast?

Across 329 Part D plans, Apremilast averages $93.18/unit (NADAC). Lowest available: $89.95/unit. Highest in distribution: $98.89/unit.

Is Apremilast on the FDA shortage list?

No. Apremilast is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Phosphodiesterase 4 Inhibitor2 alternatives in D1
01
Crisaborole
Brand: Eucrisa
$10.68Lowest NADAC
0Generic mfrs
$13.7MCY24 Part D spend
Compare →
02
Roflumilast
Brand: Daliresp
$0.312Lowest NADAC
9Generic mfrs
$101.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (3 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.