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Live data · NADAC + Part D CY24 · reviewed daily

Brexpiprazole (Rexulti)

Brexpiprazole treats schizophrenia, bipolar disorder, and related conditions by modulating dopamine and serotonin receptors.

First FDA approval2015-07-10
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$1.37B in CY2024 Part D spend972K claims · 179K beneficiaries · 329 plans surveyed

Lowest NADAC
$49.50/unit
6 NDCs benchmarked, lowest of all strengths.
Average NADAC
$49.60
Across all dosage forms in distribution.
Highest NADAC
$49.65
Range is tight.
Plans with PA
750 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Brexpiprazole used for?

Brexpiprazole treats schizophrenia, bipolar disorder, and related conditions by modulating dopamine and serotonin receptors.

Is there a generic for Brexpiprazole?

Yes. 6 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Brexpiprazole?

Across 329 Part D plans, Brexpiprazole averages $49.60/unit (NADAC). Lowest available: $49.50/unit. Highest in distribution: $49.65/unit.

Is Brexpiprazole on the FDA shortage list?

No. Brexpiprazole is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Atypical Antipsychotic6 alternatives in D1
01
Aripiprazole
Brand: ABILIFY
$0.098Lowest NADAC
22Generic mfrs
$1.45BCY24 Part D spend
Compare →
02
Aripiprazole Oral
Brand: Aripiprazole
$0.320Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Aripiprazole Orally Disintegrating
Brand: Aripiprazole
$2.87Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Asenapine
Brand: Asenapine
$2.23Lowest NADAC
3Generic mfrs
$44.6MCY24 Part D spend
Compare →
05
Cariprazine
Brand: Vraylar
$50.91Lowest NADAC
0Generic mfrs
$1.75BCY24 Part D spend
Compare →
06
Clozapine
Brand: Clozaril
$0.263Lowest NADAC
5Generic mfrs
$161.9MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (6 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.