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Live data · NADAC + Part D CY24 · reviewed daily

Buprenorphine and Naloxone Hydrochloride

Partial Opioid Agonist class · 0 generic manufacturers · 0 ANDAs filed at FDA.

First FDA approval2014-06-27
Generic availableNo (brand-only)
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.481/unit
8 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.572
Across all dosage forms in distribution.
Highest NADAC
$0.662
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema7 entries indexed · 4 visible
What is Buprenorphine and Naloxone Hydrochloride used for?

Buprenorphine and Naloxone Hydrochloride is a Partial Opioid Agonist medication tracked in Medicare Part D.

Is there a generic for Buprenorphine and Naloxone Hydrochloride?

No. Buprenorphine and Naloxone Hydrochloride is brand-only with no generic equivalents currently in market.

How much does my plan pay for Buprenorphine and Naloxone Hydrochloride?

Across 329 Part D plans, Buprenorphine and Naloxone Hydrochloride averages $0.572/unit (NADAC). Lowest available: $0.481/unit. Highest in distribution: $0.662/unit.

Is Buprenorphine and Naloxone Hydrochloride on the FDA shortage list?

No. Buprenorphine and Naloxone Hydrochloride is not currently on the FDA Drug Shortage Database.

3 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Partial Opioid Agonist2 alternatives in D1
01
Buprenorphine
Brand: BELBUCA
$0.294Lowest NADAC
15Generic mfrs
$536.9MCY24 Part D spend
Compare →
02
Buprenorphine and Naloxone
Brand: Buprenorphine HCl and Naloxone HCl
$0.481Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book · NADAC unit costs: CMS NADAC weekly file (8 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.