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Live data · NADAC + Part D CY24 · reviewed daily

Bupropion (BUPROPION HYDROCHLORIDE (SR))

Bupropion hydrochloride extended-release tablets (XL) are an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) (1.1) prevention of seasonal affective disorder ....

First FDA approval1996-11-15
Generic availableYes · 26 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$479.3M in CY2024 Part D spend14.9M claims · 4.2M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.068/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.068
Across all dosage forms in distribution.
Highest NADAC
$0.068
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Bupropion used for?

Bupropion hydrochloride extended-release tablets (XL) are an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) (1.1) prevention of seasonal affective disorder ....

Is there a generic for Bupropion?

Yes. 75 ANDAs filed at FDA, 26 generic manufacturers currently shipping.

How much does my plan pay for Bupropion?

Across 329 Part D plans, Bupropion averages $0.068/unit (NADAC). Lowest available: $0.068/unit. Highest in distribution: $0.068/unit.

Is Bupropion on the FDA shortage list?

No. Bupropion is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.