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Live data · NADAC + Part D CY24 · reviewed daily

Clozapine (Clozaril)

Clozapine treats schizophrenia, bipolar disorder, and related conditions by modulating dopamine and serotonin receptors.

First FDA approval1999-07-08
Generic availableYes · 5 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$161.9M in CY2024 Part D spend1.8M claims · 134K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.263/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.438
Across all dosage forms in distribution.
Highest NADAC
$0.628
Range is tight.
Plans with PA
940 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Clozapine used for?

Clozapine treats schizophrenia, bipolar disorder, and related conditions by modulating dopamine and serotonin receptors.

Is there a generic for Clozapine?

Yes. 31 ANDAs filed at FDA, 5 generic manufacturers currently shipping.

How much does my plan pay for Clozapine?

Across 329 Part D plans, Clozapine averages $0.438/unit (NADAC). Lowest available: $0.263/unit. Highest in distribution: $0.628/unit.

Is Clozapine on the FDA shortage list?

No. Clozapine is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Atypical Antipsychotic6 alternatives in D1
01
Aripiprazole
Brand: ABILIFY
$0.098Lowest NADAC
22Generic mfrs
$1.45BCY24 Part D spend
Compare →
02
Aripiprazole Oral
Brand: Aripiprazole
$0.320Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Aripiprazole Orally Disintegrating
Brand: Aripiprazole
$2.87Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Asenapine
Brand: Asenapine
$2.23Lowest NADAC
3Generic mfrs
$44.6MCY24 Part D spend
Compare →
05
Brexpiprazole
Brand: Rexulti
$49.50Lowest NADAC
1Generic mfrs
$1.37BCY24 Part D spend
Compare →
06
Cariprazine
Brand: Vraylar
$50.91Lowest NADAC
0Generic mfrs
$1.75BCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.