A BuiltForAI Property
Live data · NADAC + Part D CY24 · reviewed daily

Desipramine (Desipramine Hydrochloride)

Desipramine treats depression and chronic pain by blocking reuptake of serotonin and norepinephrine.

First FDA approval1964-11-20
Generic availableYes · 5 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$4.9M in CY2024 Part D spend80K claims · 22K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.146/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.186
Across all dosage forms in distribution.
Highest NADAC
$0.345
Range is tight.
Plans with PA
462 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Desipramine used for?

Desipramine treats depression and chronic pain by blocking reuptake of serotonin and norepinephrine.

Is there a generic for Desipramine?

Yes. 30 ANDAs filed at FDA, 5 generic manufacturers currently shipping.

How much does my plan pay for Desipramine?

Across 329 Part D plans, Desipramine averages $0.186/unit (NADAC). Lowest available: $0.146/unit. Highest in distribution: $0.345/unit.

Is Desipramine on the FDA shortage list?

Desipramine has been discontinued by its manufacturer(s).

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Tricyclic Antidepressant6 alternatives in D1
01
Amitriptyline
Tricyclic Antidepressant
$0.035Lowest NADAC
10Generic mfrs
$82.0MCY24 Part D spend
Compare →
02
Amoxapine
Tricyclic Antidepressant
Lowest NADAC
2Generic mfrs
$278,639CY24 Part D spend
Compare →
03
Clomipramine
Brand: ANAFRANIL
$0.203Lowest NADAC
13Generic mfrs
$22.2MCY24 Part D spend
Compare →
04
Doxepin
Brand: Doxepin
$0.078Lowest NADAC
25Generic mfrs
$99.4MCY24 Part D spend
Compare →
05
Imipramine
Tricyclic Antidepressant
$0.083Lowest NADAC
7Generic mfrs
$6.9MCY24 Part D spend
Compare →
06
Nortriptyline
Brand: PAMELOR
$0.123Lowest NADAC
5Generic mfrs
$31.8MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.