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Desvenlafaxine (Desvenlafaxine)

Desvenlafaxine treats depression, anxiety, and nerve pain by increasing serotonin and norepinephrine.

First FDA approval2008-05-01
Generic availableYes · 9 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$104.4M in CY2024 Part D spend1.5M claims · 356K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.433/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.435
Across all dosage forms in distribution.
Highest NADAC
$0.440
Range is tight.
Plans with PA
2 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema8 entries indexed · 4 visible
What is Desvenlafaxine used for?

Desvenlafaxine treats depression, anxiety, and nerve pain by increasing serotonin and norepinephrine.

Sources: CMS Part D Spending CY24 · CMS NADAC weekly · FDA Orange Book
Is there a generic for Desvenlafaxine?

Yes. 28 ANDAs filed at FDA, 9 generic manufacturers currently shipping.

Sources: CMS Part D Spending CY24 · CMS NADAC weekly · FDA Orange Book
How much does my plan pay for Desvenlafaxine?

Across 329 Part D plans, Desvenlafaxine averages $0.435/unit (NADAC). Lowest available: $0.433/unit. Highest in distribution: $0.440/unit.

Sources: CMS Part D Spending CY24 · CMS NADAC weekly · FDA Orange Book
Is Desvenlafaxine on the FDA shortage list?

No. Desvenlafaxine is not currently on the FDA Drug Shortage Database.

Sources: CMS Part D Spending CY24 · CMS NADAC weekly · FDA Orange Book

4 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Related questions.

Q&A librarySourced · reviewed quarterly
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Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.