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Live data · NADAC + Part D CY24 · reviewed daily

Dornase Alfa (Pulmozyme)

Recombinant Human Deoxyribonuclease 1 class · 0 generic manufacturers · 0 ANDAs filed at FDA.

First FDA approval1993-12-30
Generic availableNo (brand-only)
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$3.3M in CY2024 Part D spend675 claims · 180 beneficiaries · 329 plans surveyed

Lowest NADAC
$53.25/unit
1 NDCs benchmarked, lowest of all strengths.
Average NADAC
$53.25
Across all dosage forms in distribution.
Highest NADAC
$53.25
Range is tight.
Plans with PA
326 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema9 entries indexed · 4 visible
What is Dornase Alfa used for?

Dornase Alfa is a Recombinant Human Deoxyribonuclease 1 medication tracked in Medicare Part D.

Is there a generic for Dornase Alfa?

No. Dornase Alfa is brand-only with no generic equivalents currently in market.

How much does my plan pay for Dornase Alfa?

Across 329 Part D plans, Dornase Alfa averages $53.25/unit (NADAC). Lowest available: $53.25/unit. Highest in distribution: $53.25/unit.

Is Dornase Alfa on the FDA shortage list?

No. Dornase Alfa is not currently on the FDA Drug Shortage Database.

5 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book · NADAC unit costs: CMS NADAC weekly file (1 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.