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Live data · NADAC + Part D CY24 · reviewed daily

Drospirenone and Estradiol (Angeliq)

Drospirenone and Estradiol supplements estrogen levels, used in hormone replacement therapy and contraception.

First FDA approval2005-11-28
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$6.36/unit
2 NDCs benchmarked, lowest of all strengths.
Average NADAC
$6.37
Across all dosage forms in distribution.
Highest NADAC
$6.38
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Drospirenone and Estradiol used for?

Drospirenone and Estradiol supplements estrogen levels, used in hormone replacement therapy and contraception.

Is there a generic for Drospirenone and Estradiol?

Yes. 1 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Drospirenone and Estradiol?

Across 329 Part D plans, Drospirenone and Estradiol averages $6.37/unit (NADAC). Lowest available: $6.36/unit. Highest in distribution: $6.38/unit.

Is Drospirenone and Estradiol on the FDA shortage list?

No. Drospirenone and Estradiol is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Estrogen6 alternatives in D1
01
Estradiol
Brand: Climara
$0.059Lowest NADAC
21Generic mfrs
$605.7MCY24 Part D spend
Compare →
02
Norethindrone and Ethinyl Estradiol
Brand: ALYACEN 1/35
$0.128Lowest NADAC
17Generic mfrs
CY24 Part D spend
Compare →
03
Levonorgestrel and Ethinyl Estradiol
Brand: ALTAVERA
$0.112Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Norethindrone and Ethinyl Estradiol and Ferrous
Brand: AUROVELA Fe
$0.128Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Estrogens, Conjugated
Brand: Conjugated Estrogens
$5.24Lowest NADAC
1Generic mfrs
$367.7MCY24 Part D spend
Compare →
06
Estradiol and Norethindrone
Brand: ABIGALE
$0.659Lowest NADAC
6Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (3 approvals on file) · NADAC unit costs: CMS NADAC weekly file (2 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.