Live data · NADAC + Part D CY24 · reviewed daily

Epinephrine (Adrenalin)

Epinephrine is indicated for emergency treatment of type I allergic reactions including anaphylaxis to stinging insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

First FDA approval1987-12-22
Generic availableYes · 6 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$182.9M in CY2024 Part D spend875K claims · 718K beneficiaries · 329 plans surveyed

Lowest NADAC
$1.19/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$142.56
Across all dosage forms in distribution.
Highest NADAC
$359.49
Wide spread — brand-strength NDCs still in market.
Plans with PA
0 / 329
Zero PA friction across surveyed plans.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Epinephrine used for?

Epinephrine is indicated for emergency treatment of type I allergic reactions including anaphylaxis to stinging insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

Is there a generic for Epinephrine?

Yes. 10 ANDAs filed at FDA, 6 generic manufacturers currently shipping.

How much does my plan pay for Epinephrine?

Across 329 Part D plans, Epinephrine averages $142.56/unit (NADAC). Lowest available: $1.19/unit. Highest in distribution: $359.49/unit.

Is Epinephrine on the FDA shortage list?

Epinephrine has been discontinued by its manufacturer(s).

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Sources · every number above traces back.

Last refresh15 Oct 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.