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Ergotamine and Caffeine (Cafergot)

Ergotamine and Caffeine treats ADHD and narcolepsy by increasing dopamine and norepinephrine activity.

First FDA approval1983-10-30
Generic availableYes · 2 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
77 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Ergotamine and Caffeine used for?

Ergotamine and Caffeine treats ADHD and narcolepsy by increasing dopamine and norepinephrine activity.

Is there a generic for Ergotamine and Caffeine?

Yes. 2 ANDAs filed at FDA, 2 generic manufacturers currently shipping.

How much does my plan pay for Ergotamine and Caffeine?

NADAC pricing data not currently available for this drug.

Is Ergotamine and Caffeine on the FDA shortage list?

No. Ergotamine and Caffeine is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Central Nervous System Stimulant6 alternatives in D1
01
Acetaminophen, Caffeine, Dihydrocodeine Bitartrate
Brand: Trezix
Lowest NADAC
0Generic mfrs
CY24 Part D spend
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02
Amphetamine
Brand: Adzenys XR-ODT
$0.350Lowest NADAC
12Generic mfrs
$3.0MCY24 Part D spend
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03
Amphetamine Extended-Release
Central Nervous System Stimulant
$16.31Lowest NADAC
0Generic mfrs
CY24 Part D spend
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04
Caffeine
Brand: CAFCIT
Lowest NADAC
6Generic mfrs
CY24 Part D spend
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05
Caffeine and Sodium
Central Nervous System Stimulant
Lowest NADAC
0Generic mfrs
CY24 Part D spend
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06
Dexmethylphenidate
Brand: Focalin
$0.217Lowest NADAC
13Generic mfrs
$9.7MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (2 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.