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Live data · NADAC + Part D CY24 · reviewed daily

Fentanyl (Fentanyl system)

Fentanyl relieves moderate to severe pain by acting on opioid receptors in the brain.

First FDA approval1984-07-11
Generic availableYes · 5 mfrs
Shortage statusActive shortage
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$139.6M in CY2024 Part D spend1.2M claims · 205K beneficiaries · 329 plans surveyed

Lowest NADAC
$1.24/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$3.79
Across all dosage forms in distribution.
Highest NADAC
$9.38
Wide spread — brand-strength NDCs still in market.
Plans with PA
1102 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Fentanyl used for?

Fentanyl relieves moderate to severe pain by acting on opioid receptors in the brain.

Is there a generic for Fentanyl?

Yes. 30 ANDAs filed at FDA, 5 generic manufacturers currently shipping.

How much does my plan pay for Fentanyl?

Across 329 Part D plans, Fentanyl averages $3.79/unit (NADAC). Lowest available: $1.24/unit. Highest in distribution: $9.38/unit.

Is Fentanyl on the FDA shortage list?

Yes. Fentanyl is currently listed as an active FDA shortage.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Opioid Agonist6 alternatives in D1
01
Fentanyl Transdermal
Opioid Agonist
$5.69Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
02
Hydrocodone Bitartrate and Homatropine Methylbromide
Brand: Hycodan
$0.098Lowest NADAC
6Generic mfrs
CY24 Part D spend
Compare →
03
Hydrocodone and Apap
Brand: Norco
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Hydromorphone
Brand: Dilaudid
$0.166Lowest NADAC
8Generic mfrs
$28.7MCY24 Part D spend
Compare →
05
Levorphanol
Opioid Agonist
$10.65Lowest NADAC
5Generic mfrs
$20.6MCY24 Part D spend
Compare →
06
Loperamide
Opioid Agonist
$0.053Lowest NADAC
8Generic mfrs
$24.5MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.