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Live data · NADAC + Part D CY24 · reviewed daily

Fluoxetine (FLUOXETINE)

Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see Clinical Studies (14.1) ] .

First FDA approval1988-02-01
Generic availableYes · 24 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$148.8M in CY2024 Part D spend11.3M claims · 2.8M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.030/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.030
Across all dosage forms in distribution.
Highest NADAC
$0.030
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Fluoxetine used for?

Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see Clinical Studies (14.1) ] .

Is there a generic for Fluoxetine?

Yes. 67 ANDAs filed at FDA, 24 generic manufacturers currently shipping.

How much does my plan pay for Fluoxetine?

Across 329 Part D plans, Fluoxetine averages $0.030/unit (NADAC). Lowest available: $0.030/unit. Highest in distribution: $0.030/unit.

Is Fluoxetine on the FDA shortage list?

No. Fluoxetine is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Serotonin Reuptake Inhibitor3 alternatives in D1
01
Citalopram Hydrobromide
Brand: Citalopram
$0.026Lowest NADAC
9Generic mfrs
$78.3MCY24 Part D spend
Compare →
02
Escitalopram Oxalate
Brand: Escitalopram
$0.041Lowest NADAC
14Generic mfrs
$245.8MCY24 Part D spend
Compare →
03
Fluvoxamine
Serotonin Reuptake Inhibitor
$0.180Lowest NADAC
7Generic mfrs
$35.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.