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Live data · NADAC + Part D CY24 · reviewed daily

Glyburide and Metformin

Glyburide and Metformin stimulates insulin release from the pancreas to lower blood sugar.

First FDA approval2007-11-14
Generic availableYes · 5 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.192/unit
8 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.195
Across all dosage forms in distribution.
Highest NADAC
$0.198
Range is tight.
Plans with PA
108 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema8 entries indexed · 4 visible
What is Glyburide and Metformin used for?

Glyburide and Metformin stimulates insulin release from the pancreas to lower blood sugar.

Is there a generic for Glyburide and Metformin?

Yes. 15 ANDAs filed at FDA, 5 generic manufacturers currently shipping.

How much does my plan pay for Glyburide and Metformin?

Across 329 Part D plans, Glyburide and Metformin averages $0.195/unit (NADAC). Lowest available: $0.192/unit. Highest in distribution: $0.198/unit.

Is Glyburide and Metformin on the FDA shortage list?

No. Glyburide and Metformin is not currently on the FDA Drug Shortage Database.

4 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Sulfonylurea6 alternatives in D1
01
Glimepiride
Sulfonylurea
$0.024Lowest NADAC
8Generic mfrs
$62.0MCY24 Part D spend
Compare →
02
Glipizide
Brand: Glucotrol
$0.036Lowest NADAC
11Generic mfrs
$138.2MCY24 Part D spend
Compare →
03
Glipizide and Metformin
Sulfonylurea
$0.219Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →
04
Glipizide-Tablets
Brand: GLIPIZIDE
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Glyburide
Sulfonylurea
$0.058Lowest NADAC
7Generic mfrs
$4.5MCY24 Part D spend
Compare →
06
Glyburide-Metformin
Sulfonylurea
$0.192Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (8 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.