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Irbesartan and Hydrochlorothiazide (Avalide)

Irbesartan and Hydrochlorothiazide lowers blood pressure by blocking angiotensin II receptors, used for hypertension and kidney protection.

First FDA approval2012-09-27
Generic availableYes · 9 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.153/unit
17 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.691
Across all dosage forms in distribution.
Highest NADAC
$8.91
Wide spread — brand-strength NDCs still in market.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Irbesartan and Hydrochlorothiazide used for?

Irbesartan and Hydrochlorothiazide lowers blood pressure by blocking angiotensin II receptors, used for hypertension and kidney protection.

Is there a generic for Irbesartan and Hydrochlorothiazide?

Yes. 21 ANDAs filed at FDA, 9 generic manufacturers currently shipping.

How much does my plan pay for Irbesartan and Hydrochlorothiazide?

Across 329 Part D plans, Irbesartan and Hydrochlorothiazide averages $0.691/unit (NADAC). Lowest available: $0.153/unit. Highest in distribution: $8.91/unit.

Is Irbesartan and Hydrochlorothiazide on the FDA shortage list?

No. Irbesartan and Hydrochlorothiazide is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Angiotensin 2 Receptor Blocker6 alternatives in D1
01
Amlodipine and Valsartan
Brand: Exforge
$0.439Lowest NADAC
8Generic mfrs
CY24 Part D spend
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02
Candesartan Cilexetil
Brand: ATACAND
$0.495Lowest NADAC
5Generic mfrs
$61.4MCY24 Part D spend
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03
Irbesartan
Brand: Avapro
$0.084Lowest NADAC
15Generic mfrs
$84.3MCY24 Part D spend
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04
Olmesartan Medoxomil
Brand: Benicar
$0.058Lowest NADAC
19Generic mfrs
$127.5MCY24 Part D spend
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05
Sacubitril and Valsartan
Brand: ENTRESTO
$0.596Lowest NADAC
14Generic mfrs
CY24 Part D spend
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06
Telmisartan
Brand: Micardis
$0.104Lowest NADAC
16Generic mfrs
$59.8MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (17 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.