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Live data · NADAC + Part D CY24 · reviewed daily

Loteprednol and Tobramycin (Zylet)

Aminoglycoside Antibacterial class · 1 generic manufacturer · 1 ANDAs filed at FDA.

First FDA approval2004-12-14
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$64.50/unit
1 NDCs benchmarked, lowest of all strengths.
Average NADAC
$64.50
Across all dosage forms in distribution.
Highest NADAC
$64.50
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Loteprednol and Tobramycin used for?

Loteprednol and Tobramycin is a Aminoglycoside Antibacterial medication tracked in Medicare Part D.

Is there a generic for Loteprednol and Tobramycin?

Yes. 1 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Loteprednol and Tobramycin?

Across 329 Part D plans, Loteprednol and Tobramycin averages $64.50/unit (NADAC). Lowest available: $64.50/unit. Highest in distribution: $64.50/unit.

Is Loteprednol and Tobramycin on the FDA shortage list?

No. Loteprednol and Tobramycin is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Aminoglycoside Antibacterial6 alternatives in D1
01
Amikacin
Brand: ARIKAYCE
$2.72Lowest NADAC
6Generic mfrs
$1.5MCY24 Part D spend
Compare →
02
Gentamicin
Brand: Gentak
$0.783Lowest NADAC
11Generic mfrs
$19.0MCY24 Part D spend
Compare →
03
Tobramycin
Brand: BETHKIS
$0.600Lowest NADAC
23Generic mfrs
$32.8MCY24 Part D spend
Compare →
04
Tobramycin Inhalation
Aminoglycoside Antibacterial
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Tobramycin Inhalation Solution
Aminoglycoside Antibacterial
$1.07Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
06
Tobramycin Ophthalmic Solution
Aminoglycoside Antibacterial
$1.02Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (2 approvals on file) · NADAC unit costs: CMS NADAC weekly file (1 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.