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Live data · NADAC + Part D CY24 · reviewed daily

Macitentan and Tadalafil (OPSYNVI)

Endothelin Receptor Antagonist class · 0 generic manufacturers · 0 ANDAs filed at FDA.

First FDA approval2024-03-22
Generic availableNo (brand-only)
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
62 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Macitentan and Tadalafil used for?

Macitentan and Tadalafil is a Endothelin Receptor Antagonist medication tracked in Medicare Part D.

Is there a generic for Macitentan and Tadalafil?

No. Macitentan and Tadalafil is brand-only with no generic equivalents currently in market.

How much does my plan pay for Macitentan and Tadalafil?

NADAC pricing data not currently available for this drug.

Is Macitentan and Tadalafil on the FDA shortage list?

No. Macitentan and Tadalafil is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Endothelin Receptor Antagonist5 alternatives in D1
01
Ambrisentan
Brand: Letairis
$8.34Lowest NADAC
8Generic mfrs
$364.6MCY24 Part D spend
Compare →
02
Aprocitentan
Brand: TRYVIO
Lowest NADAC
0Generic mfrs
$77,158CY24 Part D spend
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03
Bosentan
Brand: Tracleer
Lowest NADAC
4Generic mfrs
$48.1MCY24 Part D spend
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04
Macitentan
Brand: OPSUMIT
Lowest NADAC
5Generic mfrs
$1.87BCY24 Part D spend
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05
Sparsentan
Brand: FILSPARI
Lowest NADAC
0Generic mfrs
$48.4MCY24 Part D spend
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Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (2 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.