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Live data · NADAC + Part D CY24 · reviewed daily

Medroxyprogesterone (Depo-Provera)

Medroxyprogesterone supplements progesterone activity, used in contraception and hormone therapy.

First FDA approval1959-06-03
Generic availableYes · 6 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$12.6M in CY2024 Part D spend589K claims · 191K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.114/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$6.02
Across all dosage forms in distribution.
Highest NADAC
$19.76
Wide spread — brand-strength NDCs still in market.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Medroxyprogesterone used for?

Medroxyprogesterone supplements progesterone activity, used in contraception and hormone therapy.

Is there a generic for Medroxyprogesterone?

Yes. 10 ANDAs filed at FDA, 6 generic manufacturers currently shipping.

How much does my plan pay for Medroxyprogesterone?

Across 329 Part D plans, Medroxyprogesterone averages $6.02/unit (NADAC). Lowest available: $0.114/unit. Highest in distribution: $19.76/unit.

Is Medroxyprogesterone on the FDA shortage list?

No. Medroxyprogesterone is not currently on the FDA Drug Shortage Database.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Progestin6 alternatives in D1
01
Desogestrel and Ethinyl Estradiol
Brand: AVERI
$0.135Lowest NADAC
11Generic mfrs
CY24 Part D spend
Compare →
02
Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol
Brand: SIMLIYA
$0.168Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Drospirenone and Ethinyl Estradiol
Brand: Jasmiel
$0.157Lowest NADAC
11Generic mfrs
CY24 Part D spend
Compare →
04
Ethynodiol Diacetate and Ethinyl Estradiol
Brand: Kelnor 1/35
$0.338Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →
05
Etonogestrel
Brand: Nexplanon
Lowest NADAC
0Generic mfrs
$1.0MCY24 Part D spend
Compare →
06
Levonorgestrel
Brand: Kyleena
Lowest NADAC
0Generic mfrs
$1.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.