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Live data · NADAC + Part D CY24 · reviewed daily

Misoprostol (Cytotec)

Prostaglandin E1 Analog class · 3 generic manufacturers · 6 ANDAs filed at FDA.

First FDA approval1986-12-27
Generic availableYes · 3 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$5.3M in CY2024 Part D spend136K claims · 77K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.424/unit
18 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.588
Across all dosage forms in distribution.
Highest NADAC
$0.671
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Misoprostol used for?

Misoprostol is a Prostaglandin E1 Analog medication tracked in Medicare Part D.

Is there a generic for Misoprostol?

Yes. 6 ANDAs filed at FDA, 3 generic manufacturers currently shipping.

How much does my plan pay for Misoprostol?

Across 329 Part D plans, Misoprostol averages $0.588/unit (NADAC). Lowest available: $0.424/unit. Highest in distribution: $0.671/unit.

Is Misoprostol on the FDA shortage list?

No. Misoprostol is not currently on the FDA Drug Shortage Database.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Prostaglandin E1 Analog2 alternatives in D1
01
Dicloenac and Misoprostol
Prostaglandin E1 Analog
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
02
Diclofenac and Misoprostol
Brand: ARTHROTEC
$0.931Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (8 approvals on file) · NADAC unit costs: CMS NADAC weekly file (18 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.