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Live data · NADAC + Part D CY24 · reviewed daily

Nalbuphine

Opioid Agonist/Antagonist class · 2 generic manufacturers · 8 ANDAs filed at FDA.

First FDA approval2004-12-31
Generic availableYes · 2 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$532,092 in CY2024 Part D spend2K claims · 186 beneficiaries · 329 plans surveyed

Lowest NADAC
$4.32/unit
3 NDCs benchmarked, lowest of all strengths.
Average NADAC
$4.32
Across all dosage forms in distribution.
Highest NADAC
$4.32
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema9 entries indexed · 4 visible
What is Nalbuphine used for?

Nalbuphine is a Opioid Agonist/Antagonist medication tracked in Medicare Part D.

Is there a generic for Nalbuphine?

Yes. 8 ANDAs filed at FDA, 2 generic manufacturers currently shipping.

How much does my plan pay for Nalbuphine?

Across 329 Part D plans, Nalbuphine averages $4.32/unit (NADAC). Lowest available: $4.32/unit. Highest in distribution: $4.32/unit.

Is Nalbuphine on the FDA shortage list?

No. Nalbuphine is not currently on the FDA Drug Shortage Database.

5 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Opioid Agonist/Antagonist1 alternative in D1
01
Butorphanol
Opioid Agonist/Antagonist
$14.72Lowest NADAC
4Generic mfrs
$3.0MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (8 approvals on file) · NADAC unit costs: CMS NADAC weekly file (3 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.