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Live data · NADAC + Part D CY24 · reviewed daily

Naproxen (EC-NAPROXEN)

Naproxen reduces pain, inflammation, and fever by inhibiting prostaglandin synthesis.

First FDA approval2007-04-26
Generic availableYes · 17 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$57.0M in CY2024 Part D spend4.4M claims · 2.2M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.046/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.050
Across all dosage forms in distribution.
Highest NADAC
$0.059
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Naproxen used for?

Naproxen reduces pain, inflammation, and fever by inhibiting prostaglandin synthesis.

Is there a generic for Naproxen?

Yes. 50 ANDAs filed at FDA, 17 generic manufacturers currently shipping.

How much does my plan pay for Naproxen?

Across 329 Part D plans, Naproxen averages $0.050/unit (NADAC). Lowest available: $0.046/unit. Highest in distribution: $0.059/unit.

Is Naproxen on the FDA shortage list?

No. Naproxen is not currently on the FDA Drug Shortage Database.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Nonsteroidal Anti-inflammatory Drug6 alternatives in D1
01
Diclofenac
Brand: Cambia
$0.069Lowest NADAC
41Generic mfrs
$610.4MCY24 Part D spend
Compare →
02
Celecoxib
Brand: CELEBREX
$0.071Lowest NADAC
18Generic mfrs
$257.9MCY24 Part D spend
Compare →
03
Ibuprofen
Brand: Caldolor
$0.024Lowest NADAC
13Generic mfrs
$75.6MCY24 Part D spend
Compare →
04
Meloxicam
Brand: QAMZOVA
$0.016Lowest NADAC
13Generic mfrs
$82.8MCY24 Part D spend
Compare →
05
Etodolac
Nonsteroidal Anti-inflammatory Drug
$0.253Lowest NADAC
11Generic mfrs
$15.9MCY24 Part D spend
Compare →
06
Nabumetone
Brand: RELAFEN DS
$0.128Lowest NADAC
8Generic mfrs
$20.7MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.