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Live data · NADAC + Part D CY24 · reviewed daily

Neostigmine Methylsulfate (Bloxiverz)

Neostigmine Methylsulfate slows cognitive decline in Alzheimer's disease by preserving acetylcholine levels.

First FDA approval2015-01-08
Generic availableYes · 14 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Neostigmine Methylsulfate used for?

Neostigmine Methylsulfate slows cognitive decline in Alzheimer's disease by preserving acetylcholine levels.

Is there a generic for Neostigmine Methylsulfate?

Yes. 30 ANDAs filed at FDA, 14 generic manufacturers currently shipping.

How much does my plan pay for Neostigmine Methylsulfate?

NADAC pricing data not currently available for this drug.

Is Neostigmine Methylsulfate on the FDA shortage list?

Neostigmine Methylsulfate has been discontinued by its manufacturer(s).

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Cholinesterase Inhibitor4 alternatives in D1
01
Donepezil
Brand: Aricept
$0.044Lowest NADAC
20Generic mfrs
$158.0MCY24 Part D spend
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02
Malathion
Brand: Ovide
$3.19Lowest NADAC
1Generic mfrs
$515,631CY24 Part D spend
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03
Pyridostigmine
Brand: Mestinon
$0.273Lowest NADAC
11Generic mfrs
$57.5MCY24 Part D spend
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04
Rivastigmine
Brand: Exelon
$0.150Lowest NADAC
13Generic mfrs
$145.3MCY24 Part D spend
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Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.