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Norethindrone and Ethinyl Estradiol (ALYACEN 1/35)

Norethindrone and Ethinyl Estradiol supplements estrogen levels, used in hormone replacement therapy and contraception.

First FDA approval2001-06-06
Generic availableYes · 17 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.128/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.170
Across all dosage forms in distribution.
Highest NADAC
$0.204
Range is tight.
Plans with PA
40 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Norethindrone and Ethinyl Estradiol used for?

Norethindrone and Ethinyl Estradiol supplements estrogen levels, used in hormone replacement therapy and contraception.

Is there a generic for Norethindrone and Ethinyl Estradiol?

Yes. 76 ANDAs filed at FDA, 17 generic manufacturers currently shipping.

How much does my plan pay for Norethindrone and Ethinyl Estradiol?

Across 329 Part D plans, Norethindrone and Ethinyl Estradiol averages $0.170/unit (NADAC). Lowest available: $0.128/unit. Highest in distribution: $0.204/unit.

Is Norethindrone and Ethinyl Estradiol on the FDA shortage list?

No. Norethindrone and Ethinyl Estradiol is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Estrogen6 alternatives in D1
01
Estradiol
Brand: Climara
$0.059Lowest NADAC
21Generic mfrs
$605.7MCY24 Part D spend
Compare →
02
Levonorgestrel and Ethinyl Estradiol
Brand: ALTAVERA
$0.112Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Norethindrone and Ethinyl Estradiol and Ferrous
Brand: AUROVELA Fe
$0.128Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Estrogens, Conjugated
Brand: Conjugated Estrogens
$5.24Lowest NADAC
1Generic mfrs
$367.7MCY24 Part D spend
Compare →
05
Estradiol and Norethindrone
Brand: ABIGALE
$0.659Lowest NADAC
6Generic mfrs
CY24 Part D spend
Compare →
06
Conjugated Estrogens and Medroxyprogesterone
Brand: Premphase
$8.68Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.