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Live data · NADAC + Part D CY24 · reviewed daily

Palonosetron (Palonosetron)

Serotonin-3 Receptor Antagonist class · 13 generic manufacturers · 16 ANDAs filed at FDA.

First FDA approval2018-03-23
Generic availableYes · 13 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$409,092 in CY2024 Part D spend7K claims · 2K beneficiaries · 329 plans surveyed

Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema9 entries indexed · 4 visible
What is Palonosetron used for?

Palonosetron is a Serotonin-3 Receptor Antagonist medication tracked in Medicare Part D.

Is there a generic for Palonosetron?

Yes. 16 ANDAs filed at FDA, 13 generic manufacturers currently shipping.

How much does my plan pay for Palonosetron?

NADAC pricing data not currently available for this drug.

Is Palonosetron on the FDA shortage list?

Palonosetron has been discontinued by its manufacturer(s).

5 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Serotonin-3 Receptor Antagonist5 alternatives in D1
01
Alosetron
Brand: LOTRONEX
$2.22Lowest NADAC
4Generic mfrs
$14.6MCY24 Part D spend
Compare →
02
Fosnetupitant and Palonosetron
Brand: AKYNZEO
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
03
Granisetron
Brand: Granisetron
$1.10Lowest NADAC
13Generic mfrs
$11.1MCY24 Part D spend
Compare →
04
Netupitant and Palonosetron
Brand: AKYNZEO
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Ondansetron
Brand: ONDANSETRON
$0.064Lowest NADAC
19Generic mfrs
$218.9MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.