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Perphenazine and Amitriptyline

Perphenazine and Amitriptyline treats psychotic disorders and severe nausea by blocking dopamine receptors.

First FDA approval1988-11-10
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
122 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema8 entries indexed · 4 visible
What is Perphenazine and Amitriptyline used for?

Perphenazine and Amitriptyline treats psychotic disorders and severe nausea by blocking dopamine receptors.

Is there a generic for Perphenazine and Amitriptyline?

Yes. 5 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Perphenazine and Amitriptyline?

NADAC pricing data not currently available for this drug.

Is Perphenazine and Amitriptyline on the FDA shortage list?

No. Perphenazine and Amitriptyline is not currently on the FDA Drug Shortage Database.

4 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Phenothiazine6 alternatives in D1
01
Chlorpromazine
Brand: ChlorproMAZINE Hydrochloride
$0.186Lowest NADAC
22Generic mfrs
$75.5MCY24 Part D spend
Compare →
02
Fluphenazine
Brand: Fluphenazine Hydrochoride
$0.218Lowest NADAC
22Generic mfrs
$39.3MCY24 Part D spend
Compare →
03
Perphenazine
Phenothiazine
$0.178Lowest NADAC
9Generic mfrs
$16.7MCY24 Part D spend
Compare →
04
Prochlorperazine
Brand: Compro
$0.121Lowest NADAC
21Generic mfrs
$18.2MCY24 Part D spend
Compare →
05
Promethazine
Brand: PHENERGAN
$0.041Lowest NADAC
16Generic mfrs
$24.4MCY24 Part D spend
Compare →
06
Promethazine and Dextromethorphan Hydrobromide
Brand: Promethazine DM
$0.039Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (5 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.