Live data · NADAC + Part D CY24 · reviewed daily

Pioglitazone and Glimepiride (Duetact)

Pioglitazone and Glimepiride stimulates insulin release from the pancreas to lower blood sugar.

First FDA approval2006-07-28
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$10.46/unit
2 NDCs benchmarked, lowest of all strengths.
Average NADAC
$10.61
Across all dosage forms in distribution.
Highest NADAC
$10.76
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Pioglitazone and Glimepiride used for?

Pioglitazone and Glimepiride stimulates insulin release from the pancreas to lower blood sugar.

Is there a generic for Pioglitazone and Glimepiride?

Yes. 2 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Pioglitazone and Glimepiride?

Across 329 Part D plans, Pioglitazone and Glimepiride averages $10.61/unit (NADAC). Lowest available: $10.46/unit. Highest in distribution: $10.76/unit.

Is Pioglitazone and Glimepiride on the FDA shortage list?

No. Pioglitazone and Glimepiride is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Sulfonylurea6 alternatives in D1
01
Glimepiride
Sulfonylurea
$0.022Lowest NADAC
8Generic mfrs
$62.0MCY24 Part D spend
Compare →
02
Glipizide
Brand: Glucotrol
$0.035Lowest NADAC
11Generic mfrs
$138.2MCY24 Part D spend
Compare →
03
$0.198Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →
04
Glipizide-Tablets
Brand: GLIPIZIDE
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Glyburide
Sulfonylurea
$0.064Lowest NADAC
7Generic mfrs
$4.5MCY24 Part D spend
Compare →
06
$0.182Lowest NADAC
5Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh29 Aug 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (4 approvals on file) · NADAC unit costs: CMS NADAC weekly file (2 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.