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Live data · NADAC + Part D CY24 · reviewed daily

Pralatrexate (Folotyn)

Folate Analog Metabolic Inhibitor class · 1 generic manufacturer · 2 ANDAs filed at FDA.

First FDA approval2009-09-24
Generic availableYes · 1 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Pralatrexate used for?

Pralatrexate is a Folate Analog Metabolic Inhibitor medication tracked in Medicare Part D.

Is there a generic for Pralatrexate?

Yes. 2 ANDAs filed at FDA, 1 generic manufacturers currently shipping.

How much does my plan pay for Pralatrexate?

NADAC pricing data not currently available for this drug.

Is Pralatrexate on the FDA shortage list?

No. Pralatrexate is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Folate Analog Metabolic Inhibitor4 alternatives in D1
01
Methotrexate
Brand: JYLAMVO
$0.158Lowest NADAC
14Generic mfrs
$88.7MCY24 Part D spend
Compare →
02
Pemetrexed
Brand: AXTLE
Lowest NADAC
0Generic mfrs
$62,837CY24 Part D spend
Compare →
03
Pemetrexed Dipotassium
Folate Analog Metabolic Inhibitor
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
04
Pemetrexed Disodium
Brand: Alimta
Lowest NADAC
13Generic mfrs
$4.5MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (4 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.