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Live data · NADAC + Part D CY24 · reviewed daily

Promethazine (PHENERGAN)

Promethazine treats psychotic disorders and severe nausea by blocking dopamine receptors.

First FDA approval1973-09-19
Generic availableYes · 16 mfrs
Shortage statusActive shortage
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$24.4M in CY2024 Part D spend2.0M claims · 832K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.041/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.046
Across all dosage forms in distribution.
Highest NADAC
$0.048
Range is tight.
Plans with PA
912 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Promethazine used for?

Promethazine treats psychotic disorders and severe nausea by blocking dopamine receptors.

Is there a generic for Promethazine?

Yes. 36 ANDAs filed at FDA, 16 generic manufacturers currently shipping.

How much does my plan pay for Promethazine?

Across 329 Part D plans, Promethazine averages $0.046/unit (NADAC). Lowest available: $0.041/unit. Highest in distribution: $0.048/unit.

Is Promethazine on the FDA shortage list?

Yes. Promethazine is currently listed as an active FDA shortage.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Phenothiazine6 alternatives in D1
01
Chlorpromazine
Brand: ChlorproMAZINE Hydrochloride
$0.186Lowest NADAC
22Generic mfrs
$75.5MCY24 Part D spend
Compare →
02
Fluphenazine
Brand: Fluphenazine Hydrochoride
$0.218Lowest NADAC
22Generic mfrs
$39.3MCY24 Part D spend
Compare →
03
Perphenazine
Phenothiazine
$0.178Lowest NADAC
9Generic mfrs
$16.7MCY24 Part D spend
Compare →
04
Perphenazine and Amitriptyline
Phenothiazine
Lowest NADAC
1Generic mfrs
CY24 Part D spend
Compare →
05
Prochlorperazine
Brand: Compro
$0.121Lowest NADAC
21Generic mfrs
$18.2MCY24 Part D spend
Compare →
06
Promethazine and Dextromethorphan Hydrobromide
Brand: Promethazine DM
$0.039Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.