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Sacubitril and Valsartan (ENTRESTO)

Sacubitril and Valsartan lowers blood pressure by blocking angiotensin II receptors, used for hypertension and kidney protection.

First FDA approval2015-07-07
Generic availableYes · 14 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.596/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.596
Across all dosage forms in distribution.
Highest NADAC
$0.596
Range is tight.
Plans with PA
6 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Sacubitril and Valsartan used for?

Sacubitril and Valsartan lowers blood pressure by blocking angiotensin II receptors, used for hypertension and kidney protection.

Is there a generic for Sacubitril and Valsartan?

Yes. 42 ANDAs filed at FDA, 14 generic manufacturers currently shipping.

How much does my plan pay for Sacubitril and Valsartan?

Across 329 Part D plans, Sacubitril and Valsartan averages $0.596/unit (NADAC). Lowest available: $0.596/unit. Highest in distribution: $0.596/unit.

Is Sacubitril and Valsartan on the FDA shortage list?

No. Sacubitril and Valsartan is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Angiotensin 2 Receptor Blocker6 alternatives in D1
01
Amlodipine and Valsartan
Brand: Exforge
$0.439Lowest NADAC
8Generic mfrs
CY24 Part D spend
Compare →
02
Candesartan Cilexetil
Brand: ATACAND
$0.495Lowest NADAC
5Generic mfrs
$61.4MCY24 Part D spend
Compare →
03
Irbesartan
Brand: Avapro
$0.084Lowest NADAC
15Generic mfrs
$84.3MCY24 Part D spend
Compare →
04
Irbesartan and Hydrochlorothiazide
Brand: Avalide
$0.153Lowest NADAC
9Generic mfrs
CY24 Part D spend
Compare →
05
Olmesartan Medoxomil
Brand: Benicar
$0.058Lowest NADAC
19Generic mfrs
$127.5MCY24 Part D spend
Compare →
06
Telmisartan
Brand: Micardis
$0.104Lowest NADAC
16Generic mfrs
$59.8MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.