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Live data · NADAC + Part D CY24 · reviewed daily

Sapropterin Dihydrochloride (JAVYGTOR)

Phenylalanine Hydroxylase Activator class · 8 generic manufacturers · 17 ANDAs filed at FDA.

First FDA approval2007-12-14
Generic availableYes · 8 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$32.7M in CY2024 Part D spend4K claims · 393 beneficiaries · 329 plans surveyed

Lowest NADAC
/unit
0 NDCs benchmarked, lowest of all strengths.
Average NADAC
Across all dosage forms in distribution.
Highest NADAC
Range is tight.
Plans with PA
1103 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Sapropterin Dihydrochloride used for?

Sapropterin Dihydrochloride is a Phenylalanine Hydroxylase Activator medication tracked in Medicare Part D.

Is there a generic for Sapropterin Dihydrochloride?

Yes. 17 ANDAs filed at FDA, 8 generic manufacturers currently shipping.

How much does my plan pay for Sapropterin Dihydrochloride?

NADAC pricing data not currently available for this drug.

Is Sapropterin Dihydrochloride on the FDA shortage list?

No. Sapropterin Dihydrochloride is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.