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Live data · NADAC + Part D CY24 · reviewed daily

Semaglutide (OZEMPIC)

Semaglutide lowers blood sugar and promotes weight loss by mimicking the GLP-1 hormone, used in type 2 diabetes.

First FDA approval2020-09-30
Generic availableNo (brand-only)
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$24.17B in CY2024 Part D spend18.7M claims · 4.3M beneficiaries · 329 plans surveyed

Lowest NADAC
$33.16/unit
15 NDCs benchmarked, lowest of all strengths.
Average NADAC
$273.32
Across all dosage forms in distribution.
Highest NADAC
$653.65
Wide spread — brand-strength NDCs still in market.
Plans with PA
1984 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema13 entries indexed · 4 visible
What is Semaglutide used for?

Semaglutide lowers blood sugar and promotes weight loss by mimicking the GLP-1 hormone, used in type 2 diabetes.

Is there a generic for Semaglutide?

No. Semaglutide is brand-only with no generic equivalents currently in market.

How much does my plan pay for Semaglutide?

Across 329 Part D plans, Semaglutide averages $273.32/unit (NADAC). Lowest available: $33.16/unit. Highest in distribution: $653.65/unit.

Is Semaglutide on the FDA shortage list?

No. Semaglutide is not currently on the FDA Drug Shortage Database.

9 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

GLP-1 Receptor Agonist3 alternatives in D1
01
Dulaglutide
Brand: TRULICITY
$487.63Lowest NADAC
0Generic mfrs
$7.87BCY24 Part D spend
Compare →
02
Exenatide
Brand: Byetta
$299.50Lowest NADAC
0Generic mfrs
$18.7MCY24 Part D spend
Compare →
03
Liraglutide
Brand: Saxenda
$39.43Lowest NADAC
6Generic mfrs
$383.1MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (15 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.