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Live data · NADAC + Part D CY24 · reviewed daily

Sertraline (Zoloft)

INDICATIONS AND USAGE Major Depressive Disorder – Sertraline hydrochloride is indicated for the treatment of major depressive disorder in adults.

First FDA approval1992-02-11
Generic availableYes · 18 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$247.4M in CY2024 Part D spend24.4M claims · 6.0M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.032/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.032
Across all dosage forms in distribution.
Highest NADAC
$0.032
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Sertraline used for?

INDICATIONS AND USAGE Major Depressive Disorder – Sertraline hydrochloride is indicated for the treatment of major depressive disorder in adults.

Is there a generic for Sertraline?

Yes. 50 ANDAs filed at FDA, 18 generic manufacturers currently shipping.

How much does my plan pay for Sertraline?

Across 329 Part D plans, Sertraline averages $0.032/unit (NADAC). Lowest available: $0.032/unit. Highest in distribution: $0.032/unit.

Is Sertraline on the FDA shortage list?

No. Sertraline is not currently on the FDA Drug Shortage Database.

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Selective Serotonin Reuptake Inhibitor (SSRI)3 alternatives in D1
01
Citalopram
Brand: CITALOPRAM HYDROBROMIDE
$0.026Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
02
Escitalopram
Brand: Lexapro
$0.041Lowest NADAC
14Generic mfrs
CY24 Part D spend
Compare →
03
Paroxetine
Brand: BRISDELLE
$0.066Lowest NADAC
2Generic mfrs
$87.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.