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Live data · NADAC + Part D CY24 · reviewed daily

Spironolactone (Aldactone)

Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need ....

First FDA approval1960-01-21
Generic availableYes · 12 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$122.9M in CY2024 Part D spend14.0M claims · 4.5M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.046/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.046
Across all dosage forms in distribution.
Highest NADAC
$0.046
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Spironolactone used for?

Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need ....

Is there a generic for Spironolactone?

Yes. 32 ANDAs filed at FDA, 12 generic manufacturers currently shipping.

How much does my plan pay for Spironolactone?

Across 329 Part D plans, Spironolactone averages $0.046/unit (NADAC). Lowest available: $0.046/unit. Highest in distribution: $0.046/unit.

Is Spironolactone on the FDA shortage list?

Spironolactone has been discontinued by its manufacturer(s).

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Aldosterone Antagonist2 alternatives in D1
01
Carospir
Aldosterone Antagonist
$3.53Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
02
Eplerenone
Brand: Inspra
$0.329Lowest NADAC
8Generic mfrs
$41.6MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.