Live data · NADAC + Part D CY24 · reviewed daily

Spironolactone and Hydrochlorothiazide

Spironolactone and Hydrochlorothiazide reduces fluid retention and lowers blood pressure by increasing urine output.

First FDA approval1979-08-03
Generic availableYes · 2 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one
Lowest NADAC
$0.541/unit
6 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.541
Across all dosage forms in distribution.
Highest NADAC
$0.541
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema8 entries indexed · 4 visible
What is Spironolactone and Hydrochlorothiazide used for?

Spironolactone and Hydrochlorothiazide reduces fluid retention and lowers blood pressure by increasing urine output.

Is there a generic for Spironolactone and Hydrochlorothiazide?

Yes. 2 ANDAs filed at FDA, 2 generic manufacturers currently shipping.

How much does my plan pay for Spironolactone and Hydrochlorothiazide?

Across 329 Part D plans, Spironolactone and Hydrochlorothiazide averages $0.541/unit (NADAC). Lowest available: $0.541/unit. Highest in distribution: $0.541/unit.

Is Spironolactone and Hydrochlorothiazide on the FDA shortage list?

No. Spironolactone and Hydrochlorothiazide is not currently on the FDA Drug Shortage Database.

4 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Thiazide Diuretic6 alternatives in D1
01
$0.062Lowest NADAC
10Generic mfrs
CY24 Part D spend
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02
Hydrochlorothiazide
Brand: INZIRQO
$0.012Lowest NADAC
11Generic mfrs
$122.0MCY24 Part D spend
Compare →
03
$0.186Lowest NADAC
8Generic mfrs
CY24 Part D spend
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04
$0.175Lowest NADAC
10Generic mfrs
CY24 Part D spend
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05
$0.114Lowest NADAC
7Generic mfrs
CY24 Part D spend
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06
$0.096Lowest NADAC
8Generic mfrs
CY24 Part D spend
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Sources · every number above traces back.

Last refresh14 Jul 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (3 approvals on file) · NADAC unit costs: CMS NADAC weekly file (6 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.