A BuiltForAI Property
Live data · NADAC + Part D CY24 · reviewed daily

Tolvaptan (JYNARQUE)

JYNARQUE is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).

First FDA approval2009-05-19
Generic availableYes · 6 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$227.8M in CY2024 Part D spend21K claims · 4K beneficiaries · 329 plans surveyed

Lowest NADAC
$21.25/unit
7 NDCs benchmarked, lowest of all strengths.
Average NADAC
$21.25
Across all dosage forms in distribution.
Highest NADAC
$21.25
Range is tight.
Plans with PA
2261 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Tolvaptan used for?

JYNARQUE is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).

Is there a generic for Tolvaptan?

Yes. 21 ANDAs filed at FDA, 6 generic manufacturers currently shipping.

How much does my plan pay for Tolvaptan?

Across 329 Part D plans, Tolvaptan averages $21.25/unit (NADAC). Lowest available: $21.25/unit. Highest in distribution: $21.25/unit.

Is Tolvaptan on the FDA shortage list?

No. Tolvaptan is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (7 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.