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Live data · NADAC + Part D CY24 · reviewed daily

Trifluoperazine

Trifluoperazine treats psychotic disorders and severe nausea by blocking dopamine receptors.

First FDA approval1981-11-20
Generic availableYes · 2 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$3.1M in CY2024 Part D spend55K claims · 10K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.377/unit
16 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.792
Across all dosage forms in distribution.
Highest NADAC
$1.30
Range is tight.
Plans with PA
180 / 329
Limited PA friction.

Questions a plan sponsor actually asks.

FAQPage schema10 entries indexed · 4 visible
What is Trifluoperazine used for?

Trifluoperazine treats psychotic disorders and severe nausea by blocking dopamine receptors.

Is there a generic for Trifluoperazine?

Yes. 8 ANDAs filed at FDA, 2 generic manufacturers currently shipping.

How much does my plan pay for Trifluoperazine?

Across 329 Part D plans, Trifluoperazine averages $0.792/unit (NADAC). Lowest available: $0.377/unit. Highest in distribution: $1.30/unit.

Is Trifluoperazine on the FDA shortage list?

No. Trifluoperazine is not currently on the FDA Drug Shortage Database.

6 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Phenothiazine6 alternatives in D1
01
Chlorpromazine
Brand: ChlorproMAZINE Hydrochloride
$0.186Lowest NADAC
22Generic mfrs
$75.5MCY24 Part D spend
Compare →
02
Fluphenazine
Brand: Fluphenazine Hydrochoride
$0.218Lowest NADAC
22Generic mfrs
$39.3MCY24 Part D spend
Compare →
03
Perphenazine
Phenothiazine
$0.178Lowest NADAC
9Generic mfrs
$16.7MCY24 Part D spend
Compare →
04
Perphenazine and Amitriptyline
Phenothiazine
Lowest NADAC
1Generic mfrs
CY24 Part D spend
Compare →
05
Prochlorperazine
Brand: Compro
$0.121Lowest NADAC
21Generic mfrs
$18.2MCY24 Part D spend
Compare →
06
Promethazine
Brand: PHENERGAN
$0.041Lowest NADAC
16Generic mfrs
$24.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (8 approvals on file) · NADAC unit costs: CMS NADAC weekly file (16 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.